Low dose erythropoietin stimulates fracture healing in small segmental defects in mice
نویسندگان
چکیده
INTRODUCTION: Despite our growing knowledge on the mechanisms of fracture healing, about 5-10% of all fractures still show delayed healing or fail to heal (Marsh, 1998). Beyond its classical role in regulation of erythropoiesis, erythropoietin (EPO) has been shown to exert protective and regenerative actions in a variety of non-hematopoietic tissues. In a previous study we could show that daily application of 5000 U/kg EPO for 5 days (high-dose, short-time) enhances early endochondral ossification and mechanical strength in a closed femoral fracture model in mice (Holstein et al., 2007). However, the initial effect of short-time and high-dose application was found vanished after 5 weeks, probably because of the good healing response of mice in the closed fracture model and limitation of EPO administration to 5 days post fracture. Therefore, the aim of the present study is to analyze the impact of low dose and long-time EPO treatment on fracture healing in segmental defects in mice.
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